Research

Publications

Find our publications on the Zurich Open Repository and Archive (ZORA).

Research Projects

CRS develops novel methodology related to reproducibility and replicability, and contributes to the improvement the quality of scientific investigation using meta-science.

See below for a summary of our research projects.

 


 

Design and Analysis of Replication Studies

Image Design and Analysis of Replication Analysis

Power Priors for Replication Studies (July 2022)

A Statistical Framework for Replicability (July 2022)

The replication of non-inferiority and equivalence studies (April 2022)

The sceptical Bayes factor for the assessment of replication success (September 2020)

Discussion on the meeting on ‘Signs and sizes: understanding and replicating statistical findings’ (February 2020)

A New Standard for the Analysis and Design of Replication Studies (December 2019)


 

Rethinking the research funding allocation process


 

How successful is bench-to-bedside translation in animal research – a systematic review

  • Benjamin Ineichen, Eva Furrer, Servan Grüninger, Malcolm MacLeod
  • Bench-to-bedside translation, e.g. eventual market approval of a therapy tested in animals, is considered to be very low in animal research (Bespalov et al., 2016). However, although bench-to-bedside translation has been assessed in certain biomedicine fields, no comprehensive analysis has investigated the extent of successful translation within different biomedicine subfields. In addition, these rates have not been systematically compared with translational rates in animal free research fields. Thus, we aim at systematically evaluating bench-to-bedside translation in biomedicine based on animal meta studies and compare the extent of bench-to-bedside translation to preclinical research fields without the use of animal experiments.

  • Preregistration on Prospero (available in June 2022)

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Assessing treatment effects and publication bias across different specialties in medicine: a large empirical study of the Cochrane Database of Systematic Reviews

Image Assessing Treatment Effects

 

Investigating the appropriate use of ANCOVA in medicine, neuroscience and psychology

  • Simon Schwab, Audrey Yeo
  • This project seeks to assess the use of analysis of covariance (ANCOVA) in various scientific fields. The work considers publications from the fields neuroscience, medicine, and psychology, as well as certain interdisciplinary subjects. Reanalysis of the original work was done to determine whether ANCOVA has been utilised appropriately. See the OSF repository of the project.

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Biostatisticians’ Impact on Quality in Medical Research (BIQMR)


 

Reseach Infrastructure

  • Forresd - Foster Open and Reproducible Reanalysis of Scientific Data 
    Simon Schwab, Eva Furrer, Leonhard Held

  • We gratefully receive funding by the StwF for this project (STWF-19-007).
    Forresd is a Linux analysis server for the CRS staff, CRS members and CRS fellows.
    The address is crs.ebpi.uzh.ch and can be accessed via SSH or x2go.
    Access from home is possible using VPN.
    More information and request account here (PDF, 449 KB).
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