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Using methodology from meta-analysis we aim quantifying and explaining the amount of heterogeneity in two different use cases. First, we use the results from RCT-DUPLICATE (https://www.rctduplicate.org/) to understand whether design differences explain variation in results between randomized trials and their non-randomized emulations. In the second case-study, we use the large-scale replication projects to further investage the methods to explain heterogeneity between the original and replication results.
Project Lead
CRS Collaborators
External Collaborators
Sebastian Schneeweiss, Shirley V Wang
Publications
Heyard, R., Held, L., Schneeweiss, S., and Wang, S. V. (2023). Design differences explain variation in results between randomized trials and their non-randomized emulations. Preprint.